英语翻译Forkhead box M1 (FOXM1) is a proliferation-associated transcription factoressential for cell cycle progression.Numerous studies have documented that FOXM1has multiple functions in tumorigenesis and its elevated levels are frequentlyassoci

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英语翻译Forkhead box M1 (FOXM1) is a proliferation-associated transcription factoressential for cell cycle progression.Numerous studies have documented that FOXM1has multiple functions in tumorigenesis and its elevated levels are frequentlyassoci
英语翻译
Forkhead box M1 (FOXM1) is a proliferation-associated transcription factor
essential for cell cycle progression.Numerous studies have documented that FOXM1
has multiple functions in tumorigenesis and its elevated levels are frequently
associated with cancer progression.Here,we characterized the role of ERK/FOXM1
signaling in mediating the metastatic potential of ovarian cancer cells.
Immunohistochemical (IHC),immunoblotting and semi-quantitative RT-PCR analyses
found that both phospho-ERK and FOXM1 were frequently upregulated in ovarian
cancers.Intriguingly,the overexpressed phospho-ERK (p

英语翻译Forkhead box M1 (FOXM1) is a proliferation-associated transcription factoressential for cell cycle progression.Numerous studies have documented that FOXM1has multiple functions in tumorigenesis and its elevated levels are frequentlyassoci
叉头框M 1(在)是一种增殖相关转录因子必不可少的细胞周期进展.无数的研究已经证明,在具有多种功能的肿瘤,其水平升高往往是与癌症相关的进展.在这里,我们的特点的作用激酶/在信号在调解转移潜能的卵巢癌细胞.免疫(免疫组化),免疫印迹和半定量RT - PCR分析发现,磷酸激酶和在经常上调卵巢癌症.有趣的是,过度磷酸化ERK(

叉头框M1(FOXM1)增殖相关的转录因子
细胞周期进程至关重要。无数的研究已经证明,FOXM1
具有多种功能和肿瘤的发生,其水平升高是经常
与癌症的发展。在这里,我们的特点作用ERK/FOXM1
信号介导的卵巢癌细胞的转移潜能。
免疫组织化学(IHC),免疫印迹和半定量RT-PCR分析
...

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叉头框M1(FOXM1)增殖相关的转录因子
细胞周期进程至关重要。无数的研究已经证明,FOXM1
具有多种功能和肿瘤的发生,其水平升高是经常
与癌症的发展。在这里,我们的特点作用ERK/FOXM1
信号介导的卵巢癌细胞的转移潜能。
免疫组织化学(IHC),免疫印迹和半定量RT-PCR分析
发现两种磷酸化ERK和FOXM1经常在卵巢上调
癌症。有趣的是,高表达磷酸化ERK(P<0.001)和FOXM1
显着正相关(P <0.001)高档卵巢肿瘤
攻击行为,如转移淋巴结(出65)。此外,
磷酸化ERK和FOXM1的表达呈显着正相关
(P <0.001)。从功能上看,异位表达FOXM1B显着增强细胞
迁移/入侵,而FOXM1C不仅增加了细胞的增殖也
促进细胞迁移/入侵。相反,抑制FOXM1表达
硫链丝菌素或U0126处理,能显着影响FOXM1介导的致癌
能力。不过,下调FOXM1的硫链丝菌素或U0126处理
所需的p53在卵巢癌细胞的存在。总的来说,我们的数据
建议FOXM1过表达可能源于组成活跃
ERK赋予卵巢癌细胞转移的能力。 “
癌细胞的转移潜能的减值FOXM1抑制剂
强调其在晚期卵巢肿瘤的治疗价值。

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