英语翻译Glycyrrhizic acid:the assessment of a no effect levelBecause from earlier experiments in rats and a pilot study in humans a no effect level of glycyrrhizic acid could not be established,a second experiment was performed in healthy volunte

英语翻译Glycyrrhizic acid:the assessment of a no effect levelBecause from earlier experiments in rats and a pilot study in humans a no effect level of glycyrrhizic acid could not be established,a second experiment was performed in healthy volunte
英语翻译
Glycyrrhizic acid:the assessment of a no effect level
Because from earlier experiments in rats and a pilot study in humans a no effect level of glycyrrhizic acid could not be established,a second experiment was performed in healthy volunteers.The experiment was performed in females only,because the effects were most marked in females in the pilot study.Doses of 0,1,2 and 4 mg glycyrrhizic acid/kg body weight were administered orally for 8 weeks to 39 healthy female volunteers aged 19-40 years.
The experimentlasted 12 weeks including an adaptation and a “wash-out” period.Ano-effectlevel of2 mg/kgis proposed from the results ofthis study,from which an acceptable daily intake (ADI) of 0.2 mg/kg body weight can be extrapolated with a safety factor of 10.This means consumption of 12 mg glycyrrhizic acid/day for a person with a body weight of 60 kg.This would be equal to 6 g licorice a day,assuming that licorice contains 0.2% of glycyrrhizic acid.
The proposed ADI is below the limit advised by the Dutch Nutrition Council of 200 mg glycyrrhizic acid/day.This reflects the relatively mild acute toxicity of glycyrrhizic acid,which is also emphasised by the “generally recognised as safe” (GRAS) status of glycyrrhizic acid in the USA in 1983.However,the long-term effects of a mild chronic intoxication (causing,for example,a mild hypertension),although not immediately lethal,justify special attention to the amount of glycyrrhizic acid used daily.
简介文字并不多,软件、网站翻译也能知道大概,但我希望能有朋友在线的回答,如果回答有帮助不能被采纳,可要求我设题补追分数.

英语翻译Glycyrrhizic acid:the assessment of a no effect levelBecause from earlier experiments in rats and a pilot study in humans a no effect level of glycyrrhizic acid could not be established,a second experiment was performed in healthy volunte
甘草酸无作用剂量分析
鉴于早期小鼠试验与人体试点研究并未确立甘草酸无作用剂量,本研究对健康受试志愿者进行进一步研究.由于试点研究中女性受试者无作用剂量较为显著,本试验仅在女性受试人群进行.39位健康女性志愿者（年龄介于19至40周岁）分别口服一定剂量（0、1、2、4 mg/kg体重）甘草酸,服用周期为8周.
试验周期为12周,包括适应期与洗胃期.结果表明无作用剂量为2mg/kg,推知日容许摄入量（ADI）为0.2mg/kg（安全系数为10）,也就是说,体重为60kg的个体其日容许摄入量为12mg.假设甘草内甘草酸含量为0.2%,等同于每天6g干草的剂量.
该研究拟定ADI水平低于荷兰营养学会（DNC）建议的200mg/天.该结果表明甘草酸急性毒理学性质相对温和.1983年美国政府政府将甘草酸列为“公认无毒”（GRAS）食品添加剂.虽然甘草酸慢性轻度中毒的长期效应（如引发轻度高血压）,有必要对日用甘草酸剂量进行适度关注.
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